Systemic Immune-Inflammation Index Is a Prognostic Predictor in Patients with Intrahepatic Cholangiocarcinoma Undergoing Liver Transplantation

Table 3

Univariate and multivariate analyses of factors related to overall survival in patients with iCCA who underwent LT.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Gender (male vs. female)	1.452	0.422-4.997	0.554
Age (years)	1.035	0.989-1.082	0.142
Child-Pugh Class (A or B vs. C)	1.579	0.629-3.964	0.331
BMI	0.960	0.823-1.120	0.605
MELD score	1.014	0.974-1.056	0.508
HBsAg (positive vs. negative)	1.336	0.531-3.359	0.538
Differentiation (well or moderate vs. poor)	1.724	0.711-4.180	0.228
AFP (ng/mL) (>20 vs. ≤20)	1.656	0.217-12.66	0.627
CEA (μg/L) (>10 vs. ≤10)	0.292	0.091-0.937	0.038	0.713	0.170-2.997	0.645
CA19-9 (U/L) (>37 vs. ≤37)	0.742	0.295-1.868	0.526	1.202	0.406-3.564	0.740
Largest tumor size (cm) (>5 vs. ≤5)	0.399	0.157-1.011	0.053	0.689	0.192-2.470	0.567
Tumor number (multiple vs. single)	1.309	0.519-3.299	0.569	1.653	0.493-5.550	0.416
Pretransplant locoregional therapy (yes vs. no)	1.218	0.467-3.177	0.687	0.760	0.214-2.698	0.671
Vascular invasion (yes vs. no)	0.543	0.197-1.496	0.237	0.547	0.164-1.823	0.326
Tumor recurrence (yes vs. no)	5.101	1.672-15.569	0.004	3.106	0.723-13.338	0.127
SII (≥447.48)	0.311	0.122-0.792	0.014	0.273	0.082-0.908	0.034
PLR (≥106.62)	0.188	0.061-0.582	0.004	0.313	0.075-1.314	0.113
NLR (≥2.92)	0.269	0.099-0.729	0.01	0.496	0.146-1.689	0.262