Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed”

<div>Mode mechanism of subtype. (a) Coexpression network of BPs in the mixed type. Each point in the network represents a kind of BP, the edges represent the correlation between functions, and the size of the edge represents the strength of the correlation. Points in the two communities are marked with different colors, and important bridge nodes are marked with orange. (b) Mechanism of immune dysfunction in mixed type. Viral infections and bacterial and fungal infections show different pathogenic pathways. Viral infections cause immune disorders by activating the overexpression of IFN; bacterial and fungal infections induce autoimmune reactions by inducing NE to produce NETs.</div>

Mediators of Inflammation

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Figure 4

Figure 4: Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed” 