Research Article
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice
Figure 1
Levels and activity of cathepsin S are upregulated in the lungs of adult βENaC-Tg mice. (a) Western blot of cathepsin S in BAL fluid from adult (6 weeks old) βENaC-Tg and WT mice ( per group). Cathepsin S activity in (b) BAL fluid from adult WT and βENaC-Tg mice ( per group) was determined using FR-AMC substrate (pH 7.5). Results expressed as change () in relative fluorescence units (ΔRFU) over time. (unpaired two-tailed -test).
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