Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult <i>β</i>ENaC-Tg Mice

<div>Cathepsin S knockdown from birth prevents airway inflammation in adult <i>β</i>ENaC-Tg mice. (a) Total cell, (b) mononuclear, and (c) polymorphonuclear (PMN) counts were quantified in BAL fluid from 6-week-old WT, CatS<sup>-/-</sup>, <i>β</i>ENaC-Tg, and CatS<sup>-/-</sup><i>β</i>ENaC-Tg mice (<svg height="8.55521pt" id="M18" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 45.009 8.55521" width="45.009pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 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89 440 131L412 140Z"></path></g></svg> per group). <span class="nowrap"><svg height="10.7395pt" id="M19" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult <i>β</i>ENaC-Tg Mice 

Mediators of Inflammation

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Figure 2