Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Figure 4

Cathepsin S knockdown from birth limits lung tissue destruction. (a) Representative images of lung sections stained with haematoxylin and eosin (H&E) used to assess airway damage. . (b) Mean linear intercept and (c) destructive index measurements were quantified from H&E-stained lung sections as detailed in materials and methods ( per group). , , (one-way ANOVA with Tukey’s multiple comparisons test).

(a)

(b)

(c)