Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Figure 7

Cathepsin S inhibition does not reduce emphysema-like lung damage. Four-week-old WT and βENaC-Tg mice were treated daily with cathepsin S inhibitor VBY-999 (CatSi, 100 mg/kg) or dextrose vehicle control (veh) for 14 days. (a) Representative images of lung sections stained with haematoxylin and eosin (H&E) used to assess airway damage. . (b) Mean linear intercept and (c) destructive index measurements were assessed from the H&E-stained lung sections as detailed in materials and methods ( per group). , , (b) one-way ANOVA with Tukey’s multiple comparisons test, (c) Kruskal-Wallis test with Dunn’s multiple comparisons test.

(a)

(b)

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