The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors
AM-251 and AMG-9810 pretreatment reversed the inhibitory effects of AEA on inflammasome components. Effect of various concentrations of AM-251 and AMG-9810 on IL-1β secretion in (b) AEA-treated AGS cells. (b) qRT-PCR and (c) Western blot of inflammasome-related genes in LPS-stimulated AGS cells in the presence or absence of AM-251 and AMG-9810. All experiments were performed in triplicate, and the results were obtained from at least two independent experiments. Data are expressed as . Indicates significantly changes compared to control group, , and ;#compared to LPS group, #,##;$compared to RT group and $.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.