The Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure
Table 2
Univariate and multivariate analysis with a Cox proportional hazard model of risk factors for cardiovascular events of patients with heart failure.
Variables
Univariate analysis
Multivariate analysis (NLR)
Multivariate analysis (MPVLR)
Multivariate analysis (NLR and MPVLR)
HR
95% CI
value
HR
95% CI
value
HR
95% CI
value
HR
95% CI
value
Lower
Upper
Lower
Upper
Lower
Upper
Lower
Upper
NLR
1
1
<0.05
1
<0.05
1
<0.05
1.19
3.30
5.24
2.11
5.16
3.11
1.98
4.89
2.42
1.46
4.01
MPVLR
1
<0.05
1
<0.05
1
<0.05
1.08
2.93
5.12
1.94
4.42
2.86
1.87
4.39
1.95
1.22
3.10
BMI
-0.06
0.94
-2.70
0.90
0.98
<0.05
CVA
0.67
1.95
2.81
1.22
3.10
<0.05
Rhythm
Sinus
1
1
<0.05
1
0.02
1
<0.05
1
0.05
Atrial fibrillation
0.63
1.88
2.89
1.22
2.89
1.76
1.12
2.78
2.86
1.87
4.39
1.60
1.00
2.56
Mean BP
-0.01
0.99
-1.96
0.98
1.00
0.05
Respiratory rate
0.05
1.06
2.77
1.02
1.09
<0.05
1.05
1.00
1.09
0.04
1.05
1.00
1.09
0.03
1.05
1.00
1.09
0.04
NYHA
III
1
1
<0.05
1
1
<0.05
1
<0.05
IV
0.84
2.32
3.99
1.53
3.49
2.21
1.45
3.38
<0.05
2.14
1.39
3.31
2.16
1.40
3.34
Etiology
ACS
0.77
2.17
3.13
1.33
3.52
<0.05
2.17
1.32
3.57
<0.05
2.41
1.46
3.96
<0.05
2.33
1.41
3.86
<0.05
VHD
0.57
1.77
2.41
1.11
2.81
0.02
1.71
1.06
2.75
0.03
1.71
1.04
2.79
0.03
1.83
1.12
2.98
0.02
Medication
ACEIs
-0.54
0.58
-2.19
0.36
0.94
0.03
PLR
0.002
1.00
3.09
1.001
1.003
<0.05
MPV
0.27
1.31
2.80
1.08
1.58
<0.05
Abbreviations: NLR: neutrophil-lymphocyte ratio; MPVLR: mean platelet volume-to-lymphocyte ratio; CI: confidential interval; HR: hazard ratio; BMI: body mass index; CVA: cerebrovascular accident; BP: blood pressure; NYHA: New York Heart Association Classification; ACS: acute coronary syndrome; VHD: valvular heart disease; ACEIs: angiotensin-converting enzyme inhibitors; PLR: platelet to lymphocyte ratio; MPV: mean platelet volume.
