Mediators of Inflammation

Research Article

The Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure

Table 3

Association of NLR and MPVLR with a prognosis of subsequent cardiovascular events and mortality in patients with heart failure.


Outcome	Number of events	Crude HR	95% CI	value	Adjusted HR	95% CI	value

Cardiovascular events^a
	27	1 (reference)	1 (reference)	<0.001	1 (reference)	1 (reference)	<0.001
	69	3.30	2.11-5.16	<0.001	3.11	1.98-4.89	<0.001
	48	1 (reference)	1 (reference)	<0.001	1 (reference)	1 (reference)	<0.001
	44	2.93	1.94-4.42	<0.001	2.86	1.87-4.39	<0.001
Rehospitalization for HF^b
	26	1 (reference)	1 (reference)	0.002	1 (reference)	1 (reference)	<0.001
	36	2.23	1.34-3.69	0.002	2.70	1.58-4.61	<0.001
	25	1 (reference)	1 (reference)	0.020	1 (reference)	1 (reference)	<0.001
	35	1.84	1.10-3.08	0.020	2.84	1.59-5.07	<0.001
In-hospital death^c
	3	1 (reference)	1 (reference)	0.002	1 (reference)	1 (reference)	0.003
	18	10.62	2.46-45.81	0.002	9.54	2.19-41.40	0.003
	4	1 (reference)	1 (reference)	<0.001	1 (reference)	1 (reference)	<0.001
	15	10.43	3.45-31.55	<0.001	7.87	2.56-24.19	<0.001
Composite outcome^d
	38	1 (reference)	1 (reference)	<0.001	1 (reference)	1 (reference)	<0.001
	119	4.82	3.34-6.96	<0.001	4.76	3.29-6.89	<0.001
	50	1 (reference)	1 (reference)	<0.001	1 (reference)	1 (reference)	<0.001
	100	3.50	2.49-4.92	<0.001	3.64	2.58-5.15	<0.001

Abbreviations: NLR: neutrophil-lymphocyte ratio; MPVLR: mean platelet volume-to-lymphocyte ratio; CI: confidential interval; HR: hazard ratio; HF: heart failure; NYHA: New York Heart Association; ACS: acute coronary syndrome. ^aA multivariate Cox proportional hazard model adjusted for NYHA classification, ACS, heart rhythm, initial respiratory rate, and underlying valvular heart disease (VHD). ^bA multivariate Cox proportional hazard model adjusted for NYHA classification, ACS, taking beta-blocker, and anemia. ^cA multivariate Cox proportional hazard model adjusted for NYHA classification, initial systolic blood pressure, and initial respiratory rate. ^dA multivariate Cox proportional hazard model adjusted for NYHA classification, ACS, heart rhythm, and body mass index.