In Vitro Free Radical Scavenging Properties and Anti-Inflammatory Activity of Ilex paraguariensis (Maté) and the Ability of Its Major Chemical Markers to Inhibit the Production of Proinflammatory Mediators

Table 2

Characterization of the major phytoconstituents of Ilex paraguariensis by LC-MS.

No.	Mode	RT (min)	Expt.	Fragments	Molecular formula	PPM	Common names
1	(−)	2.70	191.0550	85.0295; 127.0399; 173.0990	C7H12O6	-3.1	Quinic acid^a
2	(−)	3.22	191.0183	85.0266; 87.0088; 111.0080; 173.0101	C6H8O7	-4.7	Citric acid^a
3	(+)	5.48	181.0734	108.0562; 122.0582; 138.0664; 163.0607	C7H8N4O2	4.4	Theobromine^b
4	(−)	5.58	353.0873	135.0445; 179.0343; 191.0550	C16H18O9	0.0	5-O-caffeoylquinic acid^b
5	(−)	5.81	341.0887	161.0267; 179.0349; 203.0353; 221.0402; 323.0784	C15H18O9	4.1	Caffeoylglucose^a
6	(−)	6.07	341.0887	161.0267; 179.0349; 203.0353; 221.0402; 323.0784	C15H18O9	4.1	Caffeoylglucose^a
7	(−)	6.34	353.0873	135.0445; 173.0451; 179.0343; 191.0550	C16H18O9	0.0	4-O-Caffeoylquinic acid^b
8	(−)	6.34	353.0873	135.0445; 173.0451; 179.0343; 191.0550	C16H18O9	0.0	3-O-Caffeoylquinic acid^b
9	(+)	6.67	195.0886	110.0723; 123.0430; 138.0664	C8H10N4O2	2.1	Caffeine^b
10	(−)	6.77	367.1033	135.0445; 173.0456; 179.0343	C17H20O9	-2.5	Feruloylquinic acid
11	(−)	7.03	515.1195	135.0445; 173.0451; 179.0343; 191.0550; 353.0873	C25H24O12	1.0	4,5-di-O-Caffeoylquinic acid^a
12	(−)	7.1	515.1195	135.0445; 173.0451; 179.0343; 191.0550; 353.0873	C25H24O12	1.0	3,5-di-O-Caffeoylquinic acid^a
13	(−)	7.4	515.1195	135.0445; 173.0451; 179.0343; 191.0550; 353.0873	C25H24O12	1.0	3,4-di-O-Caffeoylquinic acid^a
14	(−)	7.5	609.1490	301.0358; 463.0884	C27H30O16	—	Rutin^b
15	(−)	7.6	463.0884	301.0358	C21H20O12	1.5	Quercetin-glycoside
16	(−)	7.9	593.1522	285.0425	C27H30O16	2.7	Kaempferol-rhamnoglucoside

^aIdentified by data in the literature. ^bIdentified with authentic standards. Sokeng et al. [37]. Mateos et al. [36].