In Vitro Free Radical Scavenging Properties and Anti-Inflammatory Activity of Ilex paraguariensis (Maté) and the Ability of Its Major Chemical Markers to Inhibit the Production of Proinflammatory Mediators

Table 3

Effects of compounds/chemical markers at concentration present in the IA extract (at a dose of 3 μg/mL) on NOx concentrations in the RAW 264.7 macrophages induced by LPS.

Chemical markers	Chemical marker concentration (μM)	Potency
(THEO)	0.033	212.12
(NCA)	1.97	3.55
(CCA)	0.353	19.83
(CGA)	0.565	12.39
(CAF)	0.515	13.59
(RUT)	0.164	42.68

THEO: theobromine; NCA: neochlorogenic acid; CCA: cryptochlorogenic acid; CGA: chlorogenic acid; CAF: caffeine; RUT: rutin; DEX: dexamethasone (7 μM). The potency of each chemical marker is represented by a ratio among dexamethasone (at 7 μM) and the concentration of each compound in the IA extract (at a dose of 3 μg/mL; % NOx inhibition: ) ().