Cytokines and Water Distribution in Anorexia Nervosa

Table 2

Number of participants with undetectable cytokines for each cytokine in the whole sample () with median serum concentrations (pg/ml, with interquartile range) of cytokines for HC () and AN () participants, with a significance value of group comparison.

	Undetectable^# ( (%))	Healthy controls		Anorexia nervosa
			Median (IQR^†)		Median (IQR^†)
Eotaxin	0	11	208.55 (160.77, 252.76)	27	175.47 (155.93, 279.31)	0.7113
Eotaxin-3	0	11	21.36 (17.35, 29.27)	27	15.15 (11.36, 25.58)	0.1147
GM-CSF	5 (13.2%)	11	0.24 (0.06, 0.52)	22	0.19 (0.12, 0.29)	0.6060
IFN-γ	0	11	3.28 (2.68, 4.60)	27	4.64 (2.89, 8.61)	0.1185
IL-1α	0	11	1.13 (0.65, 2.09)	27	1.01 (0.65, 1.29)	0.3761
IL-1β	10 (26.3%)	7	0.21 (0.04, 0.39)	21	0.19 (0.07, 0.25)	0.6907
IL-2	19 (50%)	6	0.12 (0.04, 0.28)	13	0.15 (0.09, 0.25)	0.9301
IL-4	2 (5.3%)	11	0.07 (0.04, 0.13)	25	0.05 (0.03, 0.08)	0.2717
IL-5	4 (10.5%)	10	1.12 (0.92, 1.74)	24	1.29 (0.72, 1.72)	0.7913
IL-6	0	11	0.30 (0.13, 0.42)	27	0.49 (0.35, 1.25)	0.0054
IL-7	0	11	15.45 (10.18, 17.44)	27	12.58 (10.46, 17.27)	0.9359
IL-8	0	11	37.24 (14.00, 118.30)	27	23.09 (10.27, 103.21)	0.3106
IL-10	0	11	0.24 (0.08, 0.26)	27	0.28 (0.11, 0.37)	0.3422
IL-12/IL-23p40	0	11	117.69 (81.15, 138.62)	27	92.00 (68.06, 118.65)	0.1185
IL-12p70	4 (10.5%)	9	0.15 (0.12, 0.19)	25	0.19 (0.11, 0.36)	0.5068
IL-13	14 (36.8%)	7	3.26 (2.13, 8.50)	17	2.44 (1.17, 4.30)	0.1197
IL-15	0	11	2.44 (2.23, 2.57)	27	2.90 (2.70, 3.51)	0.0021
IL-16	0	11	178.76 (138.29, 218.50)	27	183.59 (145.14, 339.36)	0.2274
IL-17A	0	11	1.78 (1.26, 3.20)	27	1.91 (1.08, 2.59)	0.9743
IP-10	0	11	110.93 (81.79, 151.33)	27	115.99 (98.45, 207.33)	0.3937
MIP-1α	0	11	27.16 (21.11, 33.29)	27	23.02 (20.10, 35.20)	0.9230
MIP-1β	0	11	115.67 (62.12, 141.36)	27	81.06 (65.78, 110.10)	0.2809
MCP-1	0	11	208.55 (165.87, 292.65)	27	191.53 (164.41, 241.73)	0.3937
MCP-4	0	11	149.14 (93.31, 195.49)	27	120.65 (86.10, 169.37)	0.3937
TARC	0	11	477.35 (221.30, 607.12)	27	370.33 (263.01, 641.46)	0.9359
TNF-α	0	11	1.59 (1.16, 2.51)	27	1.64 (1.34, 2.42)	0.8343
TNF-β	0	11	0.86 (0.70, 1.21)	27	0.60 (0.49, 0.69)	0.0096

^#Below fit curve range. ^†25th and 75th percentile reported. Abbreviations: IQR = interquartile range; GMCSF = granulocyte-macrophage colony-stimulating factor; IFN-γ = interferon-γ; IL = interleukin; IP-10 = interferon γ-induced protein-10; MIP = macrophage inflammatory protein; MCP = monocyte chemoattractant protein; TARC = thymus and activation-regulated chemokine; TNF = tumor necrosis factor (TARC).