Research Article
Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
Figure 3
ZQT reduced the population of MDSCs but increased the population of CD8+ T cells in tumor tissue. Cells from the tumor tissue of tumor-bearing mice treated with normal saline or ZQT were analyzed by flow cytometry after staining with CD11b, Gr-1, Ly6G, Ly6C, CD3, CD4, and CD8 antibodies. (a–d) Percentages of MDSCs and T cells in tumor. (e, f) Percentages of MDSCs in tumor on days 7, 14, 21, and 28 after inoculation. . Data are expressed as the . n/s: nonstatistical significance. ; ; .
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |