RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves’ Ophthalmopathy

Figure 1

RAGE and HMGB1 expression in normal control (NC) and in Graves’ ophthalmopathy (GO) tissues. (a) Statistical analysis of RAGE and HMGB1 expression in GO tissues compared to NC. The sections were scored as described in Material and Methods. (b) Representative images of immunohistochemistry staining. B1: isotype negative control of GO tissue. B2: positive control. (a) RAGE expression on head and neck squamous cell carcinoma tissue. (b) HMGB1 expression on nasal cavity mucosa. B3: RAGE expression in GO tissue. B4: RAGE expression in NC tissue. B5: HMGB1 expression in GO tissue (arrows). B6: HMGB1 expression in NC tissue (arrows). B7: hematoxylin and eosin (H+E) staining of GO tissue. B8: H+E staining of NC tissue. value ≤ 0.05 was considered to be significant. Bar = 150 μm.

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