RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves’ Ophthalmopathy

Table 1

Clinical characterization of the Graves’ ophthalmopathy (GO) patients included in this study at the day of surgery.

Characteristics	Patients () 36 orbits	Normal controls () 15 orbits
Sex (number of patients)
Female	18	4
Male	5	11
Age (years)
Range	35-73	36-56
Median	65	46
Disease status (number of orbits)
Moderate-to-severe GO	14
Severe GO
With DON	12
With severe keratitis	10
Graves’ disease (number of patients)	23
Median CAS	2
Thyroidectomy	7
Median proptosis (mm)	23
Median IOP (mmHg)	16
Median BCVA	0.9
Median fT4 (pmol/L)	19.4
Median TRAb (U/L)	12.4
Median aTPO (U/mL)	89.3
Median aTG (U/mL)	144

Abbreviations: DON: dysthyroid optic neuropathy; CAS: clinical activity score; IOP: intraocular pressure; BCVA: best-corrected visual acuity; fT4: free thyroxine; TRAb: anti-TSHR antibodies; aTPO: antithyroid peroxidase; aTG: antithyroglobulin.