Childhood Allergy Disease, Early Diagnosis, and the Potential of Salivary Protein Biomarkers

Table 3

Salivary proteins that are involved in oncological pathologies [30].

Author, year	Proteins involved	Proteins not involved	Site of tumor
Nakashima et al., 2006	(i) Maspin; (ii) Stathmin	—	Salivary gland
Contucci et al., 2005	—	(i) Statherin	Salivary gland
An et al., 2004	(i) Transketolase; (ii) Dim1p; (iii) v-Ha-ras oncogene; (iv) Type I collagen pro alpha; (v) Tumor necrosis factor (ligand) superfamily member 4; (vi) Pirin	—	Salivary gland with metastasis
Oshiro et al., 2007	(i) Alpha-1-B-glycoprotein; (ii) Complement factor B proteins	(i) Cystatin S; (ii) Parotid secretory factor; (iii) Poly-4-hydrolase beta-subunit proteins	Head and neck
Dowling et al., 2008	(i) Beta fibrin; (ii) S100 calcium-binding protein; (iii) Transferrin; (iv) IG heavy chain constant region γ; (v) Cofilin-1; (vi) Transthyretin	—	Head and neck
Mizukawa et al., 2001	(i) Alpha-defensins; (ii) Beta-defensins	—	Oral cavity
Contucci et al., 2005	(i) Statherins	—	Oral cavity
Wong, 2006	(i) Interleukin-8 (IL-8); (ii) Thioredoxin	—	Oral cavity
Pickering et al., 2007	(i) Endothelins	—	Oral cavity
Streckfus et al., 2000	(i) c-erbB-2 protein; (ii) CA15-3	—	Breast
Tabak, 2001	(i) 15-3 cancer antigen	—	Breast