Review Article
Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma
Table 2
Some histone-modified genes, epigenetic modifications with clinical outcome.
| Genes | Epigenetic modifications | Clinical outcome | References |
| Glucocorticoid receptor (GRa) | HDAC2 downregulation | Severe asthma | [87] | Notch-1 | Hyperacetylation of H3K9, H3K14, H3K18, H3K27, and H3K16 and trimethylation of H3K4 and H3K79 | Asthma | [88] | LAT | Hypoacetylation | Asthma | [89] | SOX2 | HDAC1 upregulation | Asthma | [90] | IFN-γ, IL-17A, IL-17F, IL-4, Foxp3, RORγt | H3K4 trimethylation (H3K4me3) | Asthma/allergic diseases | [91] | IL-13, Foxp3 | Acetylation | Asthma | [92] | ORMDL3 | Hyperacetylation | Asthma | [93] | ΔNp63, STAT6, EGFR | H3K18 acetylation | Asthma | [94] | CXCL8 | H3K18 acetylation | Asthma | [95] | CCR4, CCL5 | H3K4 dimethylation | Asthma | [96] |
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