Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma

Table 3

miRNAs, epigenetic modifications, and clinical outcome.

Genes	Epigenetic modifications	Clinical outcomes	References
IL-3, IL-5, and IL-12	miR-21	Asthma	[118]
IL-12p35	miR-21	Severe asthma	[118–120]
IRAK1	miR-146a	Neutrophil migration, IL-5, IL-33 expression	[121, 122]
IL-13	Let-7	Asthma	[123]
IL-5	miR-1248	Asthma	[124]
TOM1	miR-126	Asthma/eosinophil recruitment	[125]
S1pr1	miR-155	Th2/Th1 response	[126, 127]
VEGF/Mpl, SELP, CCL26, TSLP	miR-1	Th2 inflammation/eosinophil regulation	[128, 129]
IL-4 regulator genes	miR-23, miR-27	IL-4 expression	[130]
ADRB2	miR-16	Asthma	[131]
miR-326/STIM1 axis	circHIPK3	Asthmatic airway remodeling	[132]
PTEN/A20	miR-19a	Asthma and airway remodeling	[133, 134]
VEGF	miR-15a	Asthma	[135]
TSLP	miR-19b	Asthma/airway remodeling	[136]
MMP-16, ATG7	miR-192-5p	Airway remodeling	[137]
SYK, EGFR	miR-27-b-3p	Pediatric asthma	[138]
IL-22	miR-323-3p	Asthma	[139]
HDAC4	miR-20a-5p	Allergic inflammation/asthma	[140]