Review Article
Role of Epigenetics in the Pathogenesis, Treatment, Prediction, and Cellular Transformation of Asthma
Table 3
miRNAs, epigenetic modifications, and clinical outcome.
| Genes | Epigenetic modifications | Clinical outcomes | References |
| IL-3, IL-5, and IL-12 | miR-21 | Asthma | [118] | IL-12p35 | miR-21 | Severe asthma | [118ā120] | IRAK1 | miR-146a | Neutrophil migration, IL-5, IL-33 expression | [121, 122] | IL-13 | Let-7 | Asthma | [123] | IL-5 | miR-1248 | Asthma | [124] | TOM1 | miR-126 | Asthma/eosinophil recruitment | [125] | S1pr1 | miR-155 | Th2/Th1 response | [126, 127] | VEGF/Mpl, SELP, CCL26, TSLP | miR-1 | Th2 inflammation/eosinophil regulation | [128, 129] | IL-4 regulator genes | miR-23, miR-27 | IL-4 expression | [130] | ADRB2 | miR-16 | Asthma | [131] | miR-326/STIM1 axis | circHIPK3 | Asthmatic airway remodeling | [132] | PTEN/A20 | miR-19a | Asthma and airway remodeling | [133, 134] | VEGF | miR-15a | Asthma | [135] | TSLP | miR-19b | Asthma/airway remodeling | [136] | MMP-16, ATG7 | miR-192-5p | Airway remodeling | [137] | SYK, EGFR | miR-27-b-3p | Pediatric asthma | [138] | IL-22 | miR-323-3p | Asthma | [139] | HDAC4 | miR-20a-5p | Allergic inflammation/asthma | [140] |
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