A Synthetic Curcuminoid Analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) Ameliorates Acute Airway Inflammation of Allergic Asthma in Ovalbumin-Sensitized Mice

Figure 5

The effect of BHMC on goblet cell hyperplasia in OVA-induced mice. After the BALF was collected, the lungs and trachea of the mice were processed into tissue sections ( per group) and stained with periodic acid Schiff (PAS) stain for histopathological evaluation of goblet cell hyperplasia. The representative images of lung sections from the (a) PBS group, (b) OVA group, (c) 0.1 mg/kg BHMC group, (d) 1 mg/kg BHMC group, (e) 10 mg/kg BHMC group, and (f) DEX group. The goblet cells are indicated by black arrows. The representative images of lung sections were taken at 400x magnification (40x for objective lens and 10x for ocular lens) using a light microscope. (g) The number of goblet cells in each airway was counted, and the sum of the goblet cells was divided by the total number of airways in each slide. The values are expressed as . b: and a: , significantly different from the OVA group. A: , significantly different from the N group.

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