Enhanced H3K4 Trimethylation in TNF-α Promoter Gene Locus with Cell Apoptosis in the Ventral-Medial Striatum following Opioid Withdrawal of Neonatal Rat Offspring from Morphine-Addicted Mothers

Figure 3

Prenatal opioid exposure enhanced the TNF-α expression in the ventral-medial striatum of neonatal rat offspring on P14. (a) The expression of TNF-α at mRNA level in the ventral-medial striatum of neonatal rat offspring from morphine-addicted mothers. (b) The expression of TNF-α at protein level in the ventral-medial striatum of neonatal rat offspring from morphine-addicted mothers. The groups were as follows: the control group ( rats), the early group ( rats), and the late group ( rats). The upper panel indicates representative immunoblots. β-Tubulin served as an internal standard control and was not significantly changed across lanes. Scatted dots represent the data points in each group. , compared to the control group. #p <0.05, compared to the early group.

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