Research Article
Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease
Figure 3
Downregulation of VEGFR2 or NRP1 blocks KD sera-induced hyperpermeability of HCAEC monolayers. (a) EC permeability assay upon transfection of control siRNA, VEGFR2 siRNA, or NRP1 siRNA and stimulation with medium containing 20% KD sera (pooled from 10 KD patients). (b) Effect of KD sera incubated with the indicated pharmacologic agent on EC permeability. Data are expressed as from 3 separate experiments. ; ; n.s.: not significant.
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