Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis

Figure 3

Autophagy-pyroptosis axis and potential therapeutic targets. New drugs have been developed to target every component in this axis and can be divided into upstream and downstream molecules. Prior research targeting the downstream molecules such as interleukin- (IL-) 18 and IL-1β failed. Recent advances have been made in the development of drugs targeting the upstream molecules, including inflammasomes, caspases, and GSDMD. NSAIDs: nonsteroidal anti-inflammatory drugs.