Endangered Lymphocytes: The Effects of Alloxan and Streptozotocin on Immune Cells in Type 1 Induced Diabetes

<div>Short-term diabetogenic effects of ALX and STZ on the thymus. T1D was induced as described in Methods, and (a) thymuses from the CT, ALX, and STZ groups were collected on the 15<sup>th</sup> day and characterized according to the percentage of CD3<sup>+</sup>, CD4<sup>+</sup>CD8<sup>-</sup>, CD4<sup>-</sup>CD8<sup>+</sup>, CD4<sup>+</sup>CD8<sup>+</sup>, T lymphocytes, and CD19<sup>+</sup> B lymphocytes. (b) Evaluation of structural changes in the thymus. (c) Representative microphotographs of 3 <i>μ</i>m sections of thymus tissue stained with H&amp;E (scale 200 <i>μ</i>m). The arrows indicate atrophy of the spinal region in diabetic animals induced with ALX or STZ. 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Mediators of Inflammation

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Figure 4

Figure 4: Endangered Lymphocytes: The Effects of Alloxan and Streptozotocin on Immune Cells in Type 1 Induced Diabetes 