An Aptamer-Based Antagonist against the Receptor for Advanced Glycation End-Products (RAGE) Blocks Development of Colorectal Cancer

Figure 4

Effects of Apt-RAGE on angiogenesis of HCT116 cells xenograft nude mice. (a) The average volume of tumors treated with PBS (), Ctrl-Apt (), or Apt-RAGE (). Tumor volume was measured until the end of the experiments. (b) Images of representative tumors. (c) IHC staining was performed with RAGE, p-NFκB, VEGF, or CD31 on the frozen sections. Scale bar: 50 μm. (d) Schematic illustration of the role of Apt-RAGE to inhibit in vivo tumor angiogenesis (right) by blocking the S100B/RAGE/NFκB/VEGF-A signaling pathway (left).

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