Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis

Figure 3

Pathology of the lungs after K. pneumoniae infection. Cytokine levels (TNF, IL-1β, IL-6, and IL-10) in the lungs of 12-16 mice per group 12 and 40 hours after infection with K. pneumoniae (a). The extent of inflammation in the lungs of LysM-cre × Hif1α^fl/fl mice and littermate controls scored on haematoxylin and eosin- (H&E-) stained tissue sections as total pathology score of the infected lungs from 7-8 mice per group at 12 and 40 hours after inoculation (b). Data are shown as box-and-whisker diagrams, and the LysM-cre × Hif1α^fl/fl mice were compared to littermate control (Hif1α^fl/fl) mice using the Mann-Whitney test. Representative photographs of H&E-stained tissue sections of the infected lungs from LysM-cre × Hif1α^fl/fl mice and littermate controls at 12 (c) and 40 hours (d).

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