The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

Table 1

Positive effect of ROS and antioxidant system in various events of female reproduction and pregnancy outcomes.

Oxidant/antioxidant compounds	Functional activity	Species	References
↑ expression of GSTm2	Preparation of uterus for blastocyst implantation	Mouse	[130]
↑ GPX and GSR activities	Regulator of H202 and cell death in placental progression	Sheep	[131]
Silence the expression of GPX4	Influencing embryonic brain and heart functions	Mouse	[132]
↓ hydrogen peroxide and superoxide radical	Control uterine contractions	Humans	[133]
↑ SOD1, GPX and GST activities in early pregnancy	Rescue Corpus luteum form apoptosis	Sheep	[134]
↑ CAT and GPX and oviduct GSH in estrus cycle	Govern hydrogen peroxide during fertilization	Cow	[135]
↑ expression of SOD1 in early pregnancy	Directions of luteal functions	Human	[136]
↑ CAT and GPX, and GSH in placenta tissues	Regulates hydrogen peroxide and activation of placental differentiation	Human	[137]
↑ CAT, SOD and GPX in placental and fetal tissues	Defense against ROS toxicity in feto-placental system	Human	[138]
↑ uterine peroxide at blastocyst attachment	Defense to negative effects of hydrogen peroxide actions	Rat	[139]