Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization

Figure 8

Curcumin modulates M1/M2 macrophage polarization partly via AMPK. (a) The expression of p-AMPK and AMPK protein in homogenized hearts at 7 days after MI: representative protein bands (left) and quantification of protein gray values (right), 7 mice in each group. Data were shown as the . was vs. the sham group, and # was vs. the MI group. And value was calculated by Student’s -test. (b) After being stimulated with curcumin for different times, p-AMPK and AMPK proteins in BMMs were expressed: representative protein bands (left) and quantification of protein gray values (right). Representative protein bands (c) and quantification of the grayscale value of iNOS (d), CD86 (e), Arg1 (f), and CD163 (g) protein. Each experiment was repeated 3 times independently. Data were shown as the . was vs. the LPS+IFNγ stimulation group, and # was vs. the LPS+IFNγ+Cur stimulation group. value was calculated by post hoc comparisons.

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