Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway

<div>PQQ administration attenuates airway inflammation in an OVA-induced mouse model. (a) Protocols for establishment of the OVA-induced allergic asthma mouse model and administration of PQQ. (b) Representative photomicrographs of lung sections stained with H&amp;E and examined at 100x magnification. (c) Lung pathological scores of peribronchial and perivascular inflammatory cell infiltration in asthmatic model mice and PQQ-/DXM-treated asthmatic model mice. (d) Serum IgE levels in asthmatic model mice and PQQ-/DXM-treated asthmatic model mice. 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d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> Similar results were obtained in at least three independent experiments.</div>

Mediators of Inflammation

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Figure 3

Figure 3: Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway 