Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway

Figure 6

Effects of PQQ treatment on the pSTAT1, pSTAT3, pSTAT4, and pSTAT6 signaling pathways in lung tissue and T cells. The phosphorylated STAT1, STAT3, STAT4, and STAT6 levels in lung tissue (a–d), in T cells (M-P), and STAT1, STAT3, STAT4, and STAT6 levels in lung tissue (e–h) and in T cells (Q-T), which are presented as the geometric mean fluorescent intensity (GMFI) values measured by flow cytometry (colored lines). The gray peak is the geometric mean fluorescence intensity of the blank control. The quantitative analysis of the phosphorylated and total STAT proteins in mouse lung tissue (i–l) and in T cells (u–x). The columns and error bars represent the means and SEMs ( per group). , . Similar results were obtained in at least three independent experiments.

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