Shaoyao-Gancao Decoction Promoted Microglia M2 Polarization via the IL-13-Mediated JAK2/STAT6 Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury

Figure 4

SGD boosted microglia polarization from M1 to M2 after CI/RP treatment of rats. Double immunostaining (×200) for Iba1 and CD68 or Arg-1 was performed in brain sections from the sham, MCAO, and SGD groups at three time points. The white arrows in the merged figures indicated double positive cells. (a, b) Representative images of Iba1 (red) and CD68 (green) labeling, followed by stained with DAPI (blue) in the cortex (a) and striatum (b), and statistical results were presented on the right side. (c, d) Representative images of Iba1 (red) and Arg-1 (green) labeling, followed by stained with DAPI (blue) in the cortex (c) and striatum (d), and quantitative analysis of double-positive cell counting were listed on the right side. for all images, for each group. ^#, ^## vs. sham; , vs. MCAO.

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