Retinoic Acid Receptor Gamma (RARγ) Promotes Cartilage Destruction through Positive Feedback Activation of NF-κB Pathway in Human Osteoarthritis

Figure 1

RARγ was high expression in human OA chondrocytes compared with normal chondrocytes. (a) RARγ expression in normal cartilage was analyzed by online database Pharos (https://pharos.nih.gov/).(b,c) Comparison of RARγ expression in cartilage cells of healthy people () and OA patients () by qRT-PCR (b) and IHC (c). (d) Statistical and comparative analysis of RARγ immunohistochemical staining scores in chondrocytes of healthy people and OA patients. (e) Relationship between the degree of cartilage damage and RARγ expression grade in OA patients. (f) The RARγ mRNA expression level was positively correlated with the Mankin scale of cartilage tissues (, , ). Red dotted frames in ×400 show the corresponding zone magnification in ×1000. Data were of three independent assays (; ).

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