Retinoic Acid Receptor Gamma (RARγ) Promotes Cartilage Destruction through Positive Feedback Activation of NF-κB Pathway in Human Osteoarthritis

Figure 7

(a) Illustrate the mechanism of the study. When OA occurs, synovial fibroblasts secrete the validation factor TNF-α into the articular cavity, which promotes the activation of TNF-α signaling pathway in chondrocytes and leads to an increased expression of RARγ downstream. The increased expression of RARγ in chondrocytes in turn assists the activation of NF-κB signaling pathway, thus forming a positive feedback loop that leads to downstream gene expression related to cartilage matrix degradation and inflammation, thus aggravating the development of OA.