Research Article
FAM171B as a Novel Biomarker Mediates Tissue Immune Microenvironment in Pulmonary Arterial Hypertension
Table 2
The top 20 up- and downregulated DEGs in PAH and normal samples.
| | Genes | Log2FC | AveExpr | | value | Adj. value | | | Upregulated | | | HBB | 1.905556883 | 9.856392202 | 8.817638633 | 2.05E-14 | 5.16E-11 | 22.29719033 | | POSTN | 1.706056477 | 9.004745628 | 7.883631545 | 2.56E-12 | 1.65E-09 | 17.65365235 | | HBA2 | 1.623246487 | 9.995273661 | 8.395393375 | 1.84E-13 | 3.35E-10 | 20.18546164 | | SFRP2 | 1.364599703 | 6.835061904 | 6.259692192 | 7.73E-09 | 6.77E-07 | 9.956619921 | | VCAM1 | 1.348484359 | 6.33270595 | 6.359079782 | 4.83E-09 | 4.68E-07 | 10.40761494 | | PI15 | 1.332181179 | 5.338197295 | 5.364027131 | 4.59E-07 | 1.68E-05 | 6.054507121 | | COL14A1 | 1.239026153 | 7.436785148 | 8.01864568 | 1.28E-12 | 1.03E-09 | 18.31809232 | | ASPN | 1.234775416 | 7.13255928 | 5.807955926 | 6.29E-08 | 3.53E-06 | 7.949732975 | | WIF1 | 1.190095167 | 9.744898457 | 5.996873555 | 2.64E-08 | 1.78E-06 | 8.780077328 | | RGS1 | 1.141220379 | 7.504991123 | 6.443957755 | 3.22E-09 | 3.37E-07 | 10.79526605 | | CCDC80 | 1.12913297 | 8.080546692 | 5.183353767 | 1.01E-06 | 3.04E-05 | 5.30766633 | | ENPP2 | 1.028785935 | 9.494957558 | 5.544595076 | 2.06E-07 | 8.96E-06 | 6.815449702 | | OGN | 1.012257941 | 7.501144893 | 5.987771459 | 2.75E-08 | 1.84E-06 | 8.739767044 | | GEM | 0.983757223 | 7.038971522 | 6.81826404 | 5.28E-10 | 8.31E-08 | 12.53033356 | | ESM1 | 0.978601315 | 5.94799635 | 5.374557277 | 4.38E-07 | 1.63E-05 | 6.098491469 | | HAS2 | 0.971047451 | 6.507270998 | 3.905308804 | 0.000163209 | 0.001579558 | 0.510130208 | | PDE3A | 0.937415523 | 7.215983585 | 8.816355258 | 2.07E-14 | 5.16E-11 | 22.29074747 | | AGBL1 | 0.928098439 | 6.426958445 | 5.706068912 | 1.00E-07 | 5.14E-06 | 7.507594521 | | FABP4 | 0.924223274 | 8.40626485 | 4.525883107 | 1.54E-05 | 0.000241578 | 2.725479162 | | ANGPT2 | 0.907969049 | 5.841628396 | 3.918091772 | 0.000155808 | 0.001526427 | 0.553359741 | | Downregulated | | | CSF3R | -0.802339405 | 7.69132216 | -9.322132247 | 1.46E-15 | 7.90E-12 | 24.83851182 | | AQP9 | -0.806618791 | 7.940157165 | -3.800645776 | 0.000237754 | 0.002124247 | 0.160190529 | | NKD1 | -0.807008288 | 6.232544998 | -8.187270593 | 5.40E-13 | 7.70E-10 | 19.15162494 | | FCN3 | -0.894325549 | 10.56417571 | -4.710864558 | 7.29E-06 | 0.000136457 | 3.42917004 | | MSMB | -0.923641782 | 4.535954481 | -3.117142176 | 0.002333392 | 0.012605115 | -1.939453915 | | MGAM | -0.963945588 | 5.678217693 | -5.117611008 | 1.33E-06 | 3.74E-05 | 5.039674765 | | SLCO4A1 | -0.975611085 | 7.118272517 | -5.164935589 | 1.09E-06 | 3.21E-05 | 5.232380522 | | CHIT1 | -0.981420709 | 5.221009621 | -4.628773964 | 1.02E-05 | 0.000177714 | 3.114574322 | | LOC441081 | -1.005779498 | 7.09466789 | -7.367729041 | 3.48E-11 | 9.93E-09 | 15.14314687 | | S100A8 | -1.041186811 | 10.0442234 | -5.703814773 | 1.01E-07 | 5.14E-06 | 7.497859186 | | SAA1 | -1.041252274 | 4.232431929 | -5.085585452 | 1.53E-06 | 4.18E-05 | 4.909874548 | | LCN2 | -1.051025788 | 6.391003715 | -5.901638768 | 4.10E-08 | 2.48E-06 | 8.35982061 | | SOSTDC1 | -1.098927062 | 6.477777826 | -4.589229089 | 1.19E-05 | 0.000201156 | 2.964336963 | | MS4A15 | -1.151439894 | 6.595835828 | -5.303669318 | 5.97E-07 | 2.05E-05 | 5.803351239 | | BPIFA1 | -1.157491285 | 4.694038015 | -5.103986002 | 1.41E-06 | 3.91E-05 | 4.984392023 | | RNASE2 | -1.163968826 | 5.60043777 | -7.328408686 | 4.24E-11 | 1.18E-08 | 14.95389119 | | S100A9 | -1.275518557 | 7.549020869 | -7.393186829 | 3.07E-11 | 9.17E-09 | 15.26585058 | | IL1R2 | -1.287495193 | 7.121522058 | -4.727398557 | 6.82E-06 | 0.000129741 | 3.492972276 | | S100A12 | -1.300940357 | 7.131519115 | -5.502100612 | 2.49E-07 | 1.04E-05 | 6.635105221 | | BPIFB1 | -1.955118819 | 6.8396727 | -4.829346556 | 4.48E-06 | 9.46E-05 | 3.889569936 |
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