Interleukin-27 Ameliorates Atherosclerosis in ApoE<sup>-/-</sup> Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

<div>Recombinant IL-27 reduced the levels of IFN-<i>γ</i> and IL-17A in the peripheral blood plasma <i>while increasing the levels of</i> TGF-<i>β</i> and IL-10. Related cytokines level in mice plasma was detected by ELISA. Data from both the initiation (a) and the progression (b) of atherosclerosis were shown in histogram. The meaning of “TGF-b1/100” was <i>the level of</i> TGF-<i>β</i> divided by 100. <i>Because the levels of</i> TGF-<i>β</i> were much higher than <i>the levels of</i> IL-10, IFN-<i>γ</i>, <i>and IL-17A, we used</i> “TGF-b1/100” in this Figure. <span class="nowrap"><svg height="10.7395pt" id="M260" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 68.3436 10.7395" width="68.3436pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 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Mediators of Inflammation

fig8

Figure 8

Figure 8: Interleukin-27 Ameliorates Atherosclerosis in ApoE<sup>-/-</sup> Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance 

Mediators of Inflammation

Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance

Figure 8

Interleukin-27 Ameliorates Atherosclerosis in ApoE^-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance