Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice

Figure 4

Curcumin reduces skeletal muscle loss and improved muscle function in tumor-bearing mice. (a) Statistical analysis of forelimb grip strength of three groups of mice at 0, 2, and 4 weeks after intervention (/group). (b) Statistical analysis of movement distance within 5 min in three groups of mice at the end of the experiment (/group). (c) Statistical analysis of gastrocnemius muscle weight in three groups of mice at end of the experiment (/group). (d) Comparative analysis of the gastrocnemius index of the three groups of mice at the end of the experiment (/group). (e) Statistical analysis of muscle fiber cross-sectional area in gastrocnemius HE sections of three groups of mice (/group). (f) HE staining analysis of gastrocnemius muscle in three groups (×200 magnification; scale bar: 50 μm, /group). NS: not significant; , , , and by -test, compared to the model group. Data was shown as .

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