Research Article
Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice
Figure 8
Curcumin treatment reduces ubiquitination and NF-κB activity in muscle tissue of tumor-bearing mice. (a–c) Statistical analysis of atrogin-1, MuRF-1, and NF-κB mRNA expression of mouse gastrocnemius in three groups. (d) Western blot bands of atrogin-1 and MuRF-1 protein in gastrocnemius of the three groups. (e) Western blot bands of P65 and P-P65 protein in gastrocnemius of the three groups. (f–i) Statistical analysis of atrogin-1, MuRF-1, P-65, and PP-65 protein expressions in gastrocnemius of three groups of mice. NS: not significant; , , and by -test, compared to the model group. Data was shown as .
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |
(h) |
(i) |