Preliminary Report: Osteoarthritis and Rheumatoid Arthritis Synovial Fluid Increased Osteoclastogenesis In Vitro by Monocyte Differentiation Pathway Regulating Cytokines

Table 2

Cytokine concentrations (pg/ml) of serum and synovial fluid samples used for osteoclastogenesis experiments.

	RA serum		Control serum		RA SF		OA SF
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
OPG					423	329	400	325
sRANKL					<7	—	<7	—
MIP-1b	30	1	30	12	934	1515	30	20
IL-6	7	2	<2	—	1365	1850	123	121
IFN-y	23	6	25	14	133	134	7	6
IL-1ra	37	7	5	9	2169	3304	14	24
IL-5	2	2	4	6	5	6	<2	—
GM-CSf	<3	—	<3	—	36	25	<3	—
TNF-α	34	20	28	13	95	83	4	7
RANTES	988	62	396	84	132	91	32	48
IL-2	<1	—	<1	—	7	8	<1	—
IL-1b	1	1	1	1	16	17	<1	—
Eotaxin	55	17	62	27	42	35	8	4
Basic FGF	5	5	5	5	19	18	7	4
VEGF	21	24	2	2	1066	996	346	224
PDGF-BB	1049	413	910	522	26	26	1	2
IP-10	387	114	190	52	16342	22064	332	118
IL-13	3	1	2	1	14	12	4	2
IL-4	2	0	2	0	3	3	<1	—
MCP-1	<12	4	<12	—	98	72	52	23
IL-8	<4	—	<4	—	3775	3793	19	29
MIP-1a	2	2	2	1	115	184	4	4
IL-10	6	1	<5	—	40	37	<5	—
G-CSF	40	18	27	8	77	52	14	7
IL-15	<6	—	<6	—	26	24	<6	—
IL-7	8	3	6	1	27	35	3	2
IL-12(p70)	15	5	2	2	110	86	37	16
IL-17	97	33	74	17	61	90	0	0
IL-9	58	56	18	3	28	34	<2	1