The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application

Table 1

The relationship between miRNAs, targets, and disease.

miRNAs	Target	Disease or pathophysiological process	References
miR-122, miRNA-33, and miRNA-206 miR-142a-5p	SREBP-1c	Fatty acid metabolism	[64, 117, 122]
miR-34a	PPARα	Hepatic steatosis	[109]
miR-223	NLRP3	Cholesterol metabolism	[116]
miR-128-3p	abca1, abcg1, and retinoid X receptor alpha (RXRA)	Hypercholesterolemia	[93, 94]
miR-27	(FASN), SREBP-1, SREBP-2, PPARα and PPARγ, and ApoA1, ApoB100, and ApoE3	Cholesterol metabolism	[92]
miR-33	ABCA1, ABCG1	Cholesterol metabolism	[88]
miR-337-3p, miR-191, miR-222, miR-224, miR-520d-5p, and miR-483	PCSK9	Lipid metabolism	[74–77]
miR-199a and miR-140	LDLR	Lipid metabolism	[64]