Postoperative Pulmonary Hemodynamics and Systemic Inflammatory Response in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

Table 6

Variables associated with significant postoperative cardiopulmonary events (SCAPEs).

	SCAPEs		value
	No ()	Yes ()	Univariate analysis	Multivariate analysis 1	Multivariate analysis 2
0, (%)	10; (35)	8; (73)	0.038	0.046	0.047
CD40L at baseline (upi)	4348; (2871-6863)	6163; (3642-11641)	0.078	0.291	—
IL-6 at baseline (upi)	281; (180-637)	499; (179-1267)	0.079	0.406	—
IL-8 at baseline (upi)	188; (119-351)	403; (283-618)	0.089	0.767	—
IL-16 on day 0 (upi)	1241; (956-2767)	2140; (1265-5703)	0.048	0.859	—
IL-1RA on day 0 (upi)	14181; (9916-19524)	20302; (14144-22796)	0.078	0.446	—
MIF on day 0 (upi)	7221; (6660-9356)	10851; (7224-14947)	0.021	0.059	0.023
RANTES on day 0 (upi)	49528; (41541-59176)	69437; (40039-95821)	0.080	0.451	—
SDF-1 on day 0 (upi)	4131; (2477-6277)	6584; (3931-10135)	0.075	0.878	—
NLR on day 0	7.58; (4.42-11.71)	3.79; (2.24-6.82)	0.043	0.105	—
CRP on day 2 (mg/L)	118.89; (95.70-193.51)	163.43; (136.59-213.60)	0.077	0.419	—

Variables were tested using logistic regression. Shown are those with in univariate analysis. In multivariate analysis 1, all variables were included in the model. In multivariate analysis 2, the forward LR procedure was used for variable selection. PAP/SAP_IPO: pulmonary/systemic mean arterial pressure ratio, mean of first 4 values obtained at the postoperative care unit; CRP: C-reactive protein; NLR: neutrophil to lymphocyte ratio; baseline: day 0 and day 2, respectively, preoperative determination, 4 hours after cardiopulmonary bypass and 2 days after surgery.