Thrombin Induces COX-2 and PGE<sub>2</sub> Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells

<div>Schematic diagram illustrating the proposed signaling pathway involved in thrombin-induced COX-2 expression and PGE<sub>2</sub> secretion in HTSMCs. Thrombin-induced COX-2 expression associated with PGE<sub>2</sub> generation was mediated through PAR1/G<sub>q</sub> or G<sub>i/o</sub>/PKC<i>α</i>/MAPK-dependent NF-<i>κ</i>B activation in HTSMCs.</div>

Mediators of Inflammation

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Figure 7

Figure 7: Thrombin Induces COX-2 and PGE<sub>2</sub> Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells 

Mediators of Inflammation

Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells

Figure 7

Thrombin Induces COX-2 and PGE₂ Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells