DNMT3a-Mediated Enterocyte Barrier Dysfunction Contributes to Ulcerative Colitis via Facilitating the Interaction of Enterocytes and B Cells

Figure 1

Clinical symptoms and inflammatory cell infiltration in mice with DSS-induced colitis. Mice were administered with 3.5% DSS to induce the model of colitis, and the sham group only received regular drinking water (). (a) and (b) The body weight and DAI scores were evaluated daily. (c) Mice were sacrificed, and the colons (from the cecum to proximal rectum) were collected. Representative images of the colon samples were displayed, and the average lengths of colon were determined. (d) H&E staining was performed on proximal colonic tissues, and the representative images of colon pathologic abnormalities were exhibited. vs. sham group; .

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