Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice

Figure 1

Emodin attenuates the intestinal injury of septic mice. (a) Emodin improves the survival rate of septic mice. Thirty mice of each treatment group were used for Kaplan-Meier investigation. The observation of mortality continued for 7 days, indicates significant difference compared with CLP surgery group. (b) Emodin preserves the intestinal structure of septic mice. HE staining and scanning electron microscope were employed for histopathological study. (c) Emodin suppresses the apoptosis in ileum of septic mice. The effect of emodin on apoptosis was estimated via TUNEL staining. Three fields of view were randomly selected (×400). The number of apoptotic cells was calculated in each field. (d) Quantification of intestinal injury via Chiu’s score and count of apoptotic cells.

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