MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling

Figure 5

ADSC-derived exosomal miR-181a-5p represses pulmonary outgrowth and dissemination of Klebsiella pneumonia infection. (a–d) The mice received PBS or Klebsiella pneumoniae (10⁴ CFUs). And the mice were treated with ADSCs. The CFU loads in the lung (a), liver (b), blood (c), and spleen (d) were analyzed. (e–h) The mice received PBS or Klebsiella pneumoniae (10⁴ CFUs). And the mice were treated with exosomes from ADSCs or exosomes from miR-181a-5p-treated ADSCs. The CFU loads in the lung (a), liver (b), blood (c), and spleen (d) were analyzed. . Data are presented as . Statistic significant differences were indicated: .

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