Cutaneous Wound Healing: A Review about Innate Immune Response and Current Therapeutic Applications

Figure 3

Mast cell activities during wound healing. Secretion of mediators by MCs affects several phases of wound healing. As detailed here, MCs stimulate inflammation by releasing proinflammatory mediators inducing vascular permeability and recruitment of neutrophils (left side). MCs influence the remodeling phase and scar formation by secreting proteases that cleave extracellular matrix components and by producing a variety of mediators that stimulate fibroblasts (right side).