LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling

Figure 7

Overexpression of miR-361 counteracts the protective effect of MDRL against atherosclerosis. (a) Representative images of HE-stained aortic roots from control miRNA (miR-NC) or miR-361-treated LDLR^-/- mice after intravenous injection of rAAV-MDRL. (b) Quantification of fibrous cap thickness. (c) Representative images of Masson-stained aortic roots from miR-NC or miR-361-treated LDLR^-/- mice. (d) Quantification of collagen content. (e) Representative images of Oil red O-stained aortic roots from miR-NC or miR-361-treated LDLR^-/- mice. (f) Quantification of plaque area. Scale bar: 200 μm. Data are presented as mean ± SEM. vs miR-NC group.

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