Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice

Figure 5

CR treatment reduced the expression of itch-related molecules in IMQ-induced PsD in mice. (a) mRNA expression of Sp, Cgrp, and Ngf in skins was detected by RT-qPCR. mice in the control group and mice in both the IMQ group and IMQ+CR group. Results of mRNA were normalized to Gapdh expression. (b) Representative immunohistochemical images of SP, CGRP, and NGF expression from the epidermis of back skins among groups (). (c) Mean of integrated optical density (IOD) of Sp, Cgrp, and Ngf in skins from each group. mice in three groups. Statistical analysis was performed using one-way ANOVA followed by post hoc Tukey’s test. values are indicated, .

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