Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice

Figure 7

Characterization of the mechanism of CR for psoriasis pruritus improvement. CR treatment relieves the symptoms of psoriasis pruritus by inhibiting increased mast cells and neutrophils, as well as the upregulation of the inflammatory factors IL-17a, IL-22, IL-6, CXCL8, IL-1β, and CCL20 and itch-related molecules SP, CGRP, and NGF in psoriasis.