Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes

Figure 6

Effects of C23 on IMQ-induced psoriatic mice. (a) Representative images of each group. (b) Single (erythema, scaling, and thickness) and cumulative scores of skin lesions in each group ( mice/group). (c) Representative H&E staining of back skin sections of each group. Scale  μm. (d) Microscopic quantification of epidermal hyperplasia in the back skin of mice in each group ( mice/group). (e) qRT-PCR analysis of TNF-α and IL-6 mRNA levels in the back skin of mice in each group (). (f) Western blot analysis of the phosphorylation of NF-κB p65 and ERK1/2 in skin tissues from the three groups. Data are expressed as the . , , and .

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