Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment

Figure 2

Electroacupuncture improves synaptic plasticity of hippocampal CA3–CA1 neural circuit in VCI rats. (a) Schematic representation of the hippocampal circuit and positioning of the stimulating and recording electrodes for LTP at the Shaffer collateral-CA1 synapses (CA3–CA1 LTP). (b) A schematic diagram showing the generation of LTP. (c) Successful recording of LTP via patch-clamp. (d) Quantification of LTP elicited in the CA3–CA1. (e) The I/O curves for all recorded group are summarized. (f) I/O curve recordings in the CA3–CA1 region of the hippocampus in each group of rats. (g) Representative paired-pulse ratio (PPR) with different interpulse intervals at CA3–CA1. (h) Results of PPR recordings in the hippocampal CA3–CA1 region of rats in each group. , Sham vs. 2VO; ^#, 2VO vs. EA; ^{^}, EA vs. Non-acu.

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